Which of the following amendments protects against double jeopardy?

The Fifth Amendment of the United States Constitution includes a provision that protects individuals from being tried twice for the same offense, commonly known as the protection against double jeopardy. This means that once a person has been acquitted or convicted of a crime, they cannot be prosecuted again for that same crime in the same jurisdiction. This safeguard fosters a sense of security for individuals against potential governmental abuse and ensures the integrity of legal proceedings.

The other amendments listed in the question serve different purposes. The Fourth Amendment primarily addresses issues of unreasonable searches and seizures, the Sixth Amendment focuses on the rights of defendants in criminal prosecutions—such as the right to a speedy and public trial, impartial jury, and legal counsel—while the Eighth Amendment protects against cruel and unusual punishments. Thus, these amendments do not relate to the issue of double jeopardy, confirming the Fifth Amendment's unique role in this context.